It is the most abundant protein in humans present in cartilage, tendons, ligaments, bone, extracellular matrix, basal membranes, cornea and crystalline where it binds the cellular elements giving rise to the formation of organs and tissues and giving strength and elastic properties to the same.
Collagen is a simple fibrous protein consisting of polypeptidic chains in which the mainly present amino acids are glycine, proline, hydroxyproline and hydroxylysine. Each polypeptidic chain is wrapped to form a left-helix stabilized by hydrogen bridges and three left-helixes are wrapped to form a triple right-helix which constitutes the tropo-collagen, further stabilized by cross-links, whose number and position determine the elasticity and the resistance of cells, and then the physical properties of tissue. The spontaneous extracellular polymerization of tropo-collagen units give rise to the collagen fibrils.
Collagen is largely responsible for the health of skin: it maintains the elasticity and tonicity of skin, prevents dehydration, avoiding the formation of wrinkles and providing a mechanical protection.
Hydrolyzed collagen present in Yalidema is obtained by subjecting the native collagen type I in particular processes of hydrolysis and purification that are intended to make it more easily absorbed in the intestine. In this way the cells are supplied of the amino-acidic pool necessary for stimulating the synthesis of new collagen promoting activity in the skin an anti-aging action.
In fact the normal aging process decrease by time the synthesis and then the concentration of collagen in the skin, resulting in a decrease in the turgidity, elasticity and firmness, and consequently the appearance of wrinkles and streaks. The introduction of collagen is then indicated as a preventive treatment to delay the factors that normally promote skin aging.

It is a semi-essential amino acid, present mainly in wheat, nuts, fish and meat. In the body it is converted into nitric oxide by the action of the nitric oxide synthase enzyme. Arginine is required for the execution of many physiological processes, such as hormone secretion, the increased production of hormones, the elimination of toxic substances from the body and the immune system’s defense. In the skin it exerts an anti-aging activity thanks to its high antioxidant power necessary to counteract the damage induced by free radicals and to protect cellular DNA. It also stimulates the release of growth hormone to retard aging, and helps to rebuild the blood vessels lining and to regenerate epidermal tissues.

Soy Isoflavones
They are compounds belonging to the class of phytoestrogens, plant-derived substances structurally and functionally similar to estrogen hormone produced by body. Those of particular importance are the isoflavones dadzeina and genistein. The latter in particular is one on which are focused the research because of its numerous properties and beneficial effects on our health. On the skin, genistein acts as a powerful anti-aging element. Indeed, it has been shown to exert a strong antioxidant activity, protecting the skin from damage induced by solar radiation; its intake helps maintain the thickness of the dermis; inhibits some of the dermis metal protease (MMP), which normally degrade the collagen fibers and stimulates dermal regeneration with an excellent safety profile, thus counteracting in a natural but effective way the skin aging process.

Hyaluronic Acid
It is a polysaccharide that occurs naturally in the human body. The sodium salt of hyaluronic acid is formed by the repetition of disaccharide units of N-acetylglucosamine and sodium glucuronate and represents a fundamental component of the extracellular matrix of most tissues, in particular of dermis. Its main function is to maintain a proper hydration of tissues, thanks to its intrinsic ability to bind a large amount of water molecules. Therefore appear as an high-power anti-aging element. Indeed its viscoelastic and moisturizing properties allow to maintain an adequate and natural skin hydration and consequently the turgidity of dermis, a necessary condition to ensure an optimal cell function, to promote the proliferation and the stimulation of fibroblasts activity, thus preventing and counteracting the skin aging process.

Vitamin E
It is a fat-soluble vitamin essential for humans, present in fats and in animal and vegetable oils. Vitamin E plays an important antioxidant role in the prevention of lipid peroxidation and oxidation of essential cellular constituents, triggered by the action of free radicals. Then it stabilizes cell membranes, it protects DNA and counteracts the skin aging induced by environmental pollution and UV rays (photo-aging).

Thanks to its active ingredients Yaliderma:

  • Promotes the trophism of skin due to its remarkable anti-aging activity, and it is indicated for the prevention and treatment of skin damage caused by aging
  • Induces the synthesis of hyaluronic acid, collagen and elastin, providing an optimum level of hydration of the skin
  • Improves tonicity, thickness and elasticity of the skin
  • Is particularly indicated for the treatment of skin disorders in pre-and post-menopausal (thin and dry skin, stress wrinkles, laxity of the eyelids, cheeks, chin and breast) and for the treatment of skin laxity after diet
  • Supports all treatments of Aesthetic Medicine