Cistysol Complex


Cranberry (Vacciunum macrocarpon)
The Cranberry is a small shrub belonging to the family Ericaceae native to North America and Canada, also present in Europe. The fruit is mainly composed of water and various organic compounds: flavonoids, proanthocyanidins, vitamin C and organic acids (malic, quinic and hippuric acid) .
Several clinical studies support the use of cranberry as a preventive agent and as an alternative to antibiotic prophylaxis for the treatment of urinary tract infections, especially in people predisposed to recurrent bladder infections, either occasional or chronic reccurrent.
Its beneficial effects are attributed to acidification of the urine which is obtained thanks to its high content of organic acids, but more recent studies have shown in particular that proanthocyanidins type A, contained in the cranberry, decreases the adhesion forces between the bacterium and the walls of the urinary tract by altering the conformation of adhesins, the protein structures located at the ends of fimbriae or pili, which in normal conditions allow uropathogenic bacteria to adhere to uroepithelial cell membranes, colonize and subsequently give rise to infectious process.
therefore this anti-adhesive action of Cranberry facilitates the physiological elimination of bacterial populations and can help to counteract the colonization of the urinary tract by potentially pathogenic agents.

it is one of the essential amino acids so is an important constituent of the human body. The most important natural sources of L-methionine (L- Met) are meat, milk, fish, eggs and soy protein. The L -Met is the only essential amino acid which contains sulfur in its formula and this characteristic makes it an important acidifying constitutive for the body. The presence of sulfur also allows to capture, along with other sulfur amino acids, heavy metals, highly toxic for the body and to carry out an antioxidant action, limiting the damage caused by free radicals.
L -Met participates mainly to the synthesis of proteins and takes part to a series of metabolic reactions including the formation of L-cysteine ​​and cystine, the other two sulfur containing amino acids. The availability of L -Met as a sulfur donor is in fact a necessary condition for the biosynthesis of cysteine ​​whose -SH group is oxidized to sulfate in the liver and is excreted by the kidneys; simultaneously together with sulphate, even some protons appear in the lumen of the tubules, and this physiological process underlies the acidification of the urine produced by L -Met, which is essential to decrease the adhesion and colonization of pathogenic bacteria to the cells of the urothelium and counteract the onset of urinary tract infections. Then the use of L-Met is indicated as prevention in subjects prone to recurrent urinary tract infections. The L -Met assists the action of Vitamin C in maintaining the physiological functions of the urinary system and the acidic pH of the urine.

Bromelain 2500 GDU
It is a glycoproteic proteolytic enzyme present in the fruit, but at higher concentrations in the stem of Pineapple from which is extracted (Ananas Sativus – Family Bromeliaceae). Bromelain performs an anti-inflammatory, anti-edema, digestive action, it is able to enhance the action of antibiotics and drugs. In the inflamed tissue it reduces the vasodilation, capillary permeability, leukocyte migration and the local pain, by inhibiting the thromboxane synthetase enzyme which converts prostaglandin H2 into pro-inflammatory prostaglandins and thromboxanes thus increasing the production of prostaglandins with anti-inflammatory activity to the detriment of those with pro-inflammatory activity. Hence the safe use of bromelain compared to NSAIDs that inhibit cyclooxygenase, blocking the synthesis of prostaglandins and procuring a gastrointestinal damage. It is therefore particularly effective in the treatment of tissue inflammation associated with trauma, in localized inflammations especially in the presence of edema, and in post-operative tissue reactions. It is useful in contributing to the normal functioning of the immune system thus disadvantaging the onset of disorders associated with infections of the urogenital tract.

Vitamin C (acido L-ascorbico)
It is a water soluble vitamin that is essential because humans lack the enzyme L-glucono-gamma-lactone-oxidase, the last enzyme of the biosynthetic chain that from glucose leads to the formation of ascorbic acid. Vitamin C has an high antioxidant capacity and exerts a synergistic action in combination with other antioxidants such as Vitamin E. Thanks to its high acidifying power, Vitamin C also plays an anti-infective action, and it is useful for maintaining the physiological functions of the urinary tract thus preventing the adhesion and consequently the proliferation of uropathogenic bacteria to the epithelial cells of the urinary tract. This allows to prevent infection and/or to support the antibiotic treatment in patients with urinary tract infections. Vitamin C also exerts an immunostimulant activity so it is an excellent remedy in infection.

It is a monosaccharide that attaches to the bacterial fimbriae thus substantially reducing the microbial adherence to the bladder mucosa.

Lactobacillus acidophilus
These probiotics are useful to keep in good health in the gut, preventing harmful bacteria contamination of the lower urinary tract. The vitality of these probiotics, determining the effectiveness, is preserved through a special packaging in protective atmosphere (nitrogen) that ensures the correct preservation, integrity and concentration until the date of expiration.

Thanks to the synergistic action of its active ingredients Cistysol Complex in Urology and Gynecology:

  • Allows to have a vigorous acidifying action of the urine
  • Has a anti adhesive bacterial action on the urogenital epithelium
  • Exerts a specific antioxidant action to counteract the presence of free radicals and of the products degradation of bacterial toxins produced in the case of infections
  • Exerts a probiotic colonization of the intestinal flora
  • It can be a valid support for antibiotic therapy in urinary infections.